Healthcare
Visualizing the World’s Biggest Pharmaceutical Companies

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Who are the World’s Biggest Pharmaceutical Companies?
Some of the world’s biggest pharmaceutical companies have played a central role in the COVID-19 pandemic.
However, it’s likely no surprise that the pandemic has also been great for many healthcare businesses. In fact, in 2020 alone, the world’s 50 largest pharmaceutical companies still combined for a whopping $851 billion in revenues.
In this graphic, using data from Companies Market Cap , we list the largest pharmaceutical companies in the world by market capitalization. It’s worth noting this list also includes healthcare companies that work closely with pharmaceuticals, including biotech, pharmaceutical retailers, clinical laboratories, etc.
Editor’s Note: A previous version of this graphic was missing some key companies such as GSK and AbbVie. They were unfortunately not included in the original source and we are now working to make sure there were no other smaller omissions. Thanks to all that sent in corrections.
The Pharmaceutical Leaders
To start, here are the top five biggest pharmaceutical companies in the world at the moment by market capitalization:
1. Johnson & Johnson
The pharmaceutical and consumer goods giant is worth $428.7 billion in market cap. They developed the third vaccine authorized for use in the U.S. and were named among the TIME100 Most Influential Companies List in 2021.
2. Roche
The Swiss pharmaceutical giant is at the forefront of oncology, immunology, infectious diseases, ophthalmology, and neuroscience. In 2019, Roche’s pharma segment sales rose by a healthy 16% to $53 billion .
3. Pfizer
Despite being the leading COVID-19 vaccine manufacturer in North America, Pfizer slid in the rankings to third place. The company has recently gained momentum , especially in the past quarter, with Q2’2021 revenues of $19.0 billion , reflecting a 86% operational growth from 2020.
4. Eli Lilly
Eli Lilly has taken a significant step towards establishing itself as a pharmaceutical industry leader. Having a market cap value of $125 billion in 2019, Eli Lilly has jumped to a current value of $214.9 billion, a significant growth of 72%.
5. Novartis
The second-biggest pharmaceutical company out of Switzerland, Novartis has been the face of the pharma industry for about 25 years. The primary manufacturer for the most recognizable drugs on the market pulled in a revenue of over $48 billion in 2020, a 3% increase compared to 2019.
Here’s how all the biggest pharmaceutical companies in the world stack up against each other:
Company Rank | Company Name | Market Cap Value | Country |
---|---|---|---|
1 |
Johnson & Johnson
JNJ |
$428.66 B | 🇺🇸 USA |
2 |
Roche
RHHBY |
$320.41 B | 🇨🇭 Switzerland |
3 |
Pfizer
PFE |
$219.39 B | 🇺🇸 USA |
4 |
Eli Lilly
LLY |
$208.99 B | 🇺🇸 USA |
5 |
Novartis
NVS |
$207.70 B | 🇨🇭 Switzerland |
6 |
AbbVie
ABBV |
$202.60 B | 🇺🇸 USA |
7 |
Merck
MRK |
$191.67 B | 🇺🇸 USA |
8 |
Novo Nordisk
NVO |
$187.83 B | 🇩🇰 Denmark |
9 |
Astrazeneca
AZN |
$152.28 B | 🇬🇧 UK |
10 |
Bristol-Myers Squibb
BMY |
$145.80 B | 🇺🇸 USA |
11 |
Amgen
AMGN |
$136.50 B | 🇺🇸 USA |
12 |
Sanofi
SNY |
$130.37 B | 🇫🇷 France |
13 |
CVS Health
CVS |
$110.49 B | 🇺🇸 USA |
14 |
GlaxoSmithKline
GSK |
$104.30 B | 🇬🇧 UK |
15 |
CSL
CSL.AX |
$103.10 B | 🇦🇺 Australia |
16 |
Gilead Sciences
GILD |
$83.62 B | 🇺🇸 USA |
17 |
Moderna
MRNA |
$83.25 B | 🇺🇸 USA |
18 |
Merck KGaA
MRK.DE |
$80.61 B | 🇩🇪 Germany |
19 |
Bayer
BAYZF |
$59.43 B | 🇩🇪 Germany |
20 |
Jiangsu Hengrui Medicine
600276.SS |
$58.51 B | 🇨🇳 China |
21 |
Regeneron Pharmaceuticals
REGN |
$55.83 B | 🇺🇸 USA |
22 |
Biogen
BIIB |
$55.00 B | 🇺🇸 USA |
23 |
BioNTech
BNTX |
$54.23 B | 🇩🇪 Germany |
24 |
Takeda Pharmaceutical
TAK |
$52.67 B | 🇯🇵 Japan |
25 |
Lonza
LONN.SW |
$52.16 B | 🇨🇭 Switzerland |
26 |
Walgreens Boots Alliance
WBA |
$45.05 B | 🇺🇸 USA |
27 |
Celltrion
068270.KS |
$33.80 B | 🇰🇷 S. Korea |
28 |
Astellas Pharma
ALPMF |
$33.42 B | 🇯🇵 Japan |
29 |
BeiGene
BGNE |
$31.65 B | 🇨🇳 China |
30 |
Eisai
4523.T |
$31.20 B | 🇯🇵 Japan |
31 |
West Pharma
WST |
$26.59 B | 🇺🇸 USA |
32 |
Hansoh Pharma
3692.HK |
$26.00 B | 🇨🇳 China |
33 |
LabCorp
LH |
$25.97 B | 🇺🇸 USA |
34 |
Otsuka Holdings
4578.T |
$23.15 B | 🇯🇵 Japan |
35 |
Horizon Therapeutics
HZNP |
$21.13 B | 🇮🇪 Ireland |
36 |
Alnylam Pharmaceuticals
ALNY |
$20.42 B | 🇺🇸 USA |
37 |
kyowa Kirin
4151.T |
$18.85 B | 🇯🇵 Japan |
38 |
Catalent
CTLT |
$18.74 B | 🇺🇸 USA |
39 |
Sino Biopharmaceutical
1177.HK |
$18.48 B | 🇭🇰 Hong Kong |
40 |
Bio-Techne
TECH |
$17.25 B | 🇺🇸 USA |
41 |
PPD
PPD |
$16.26 B | 🇺🇸 USA |
42 |
Argenx
ARGX |
$16.03 B | 🇳🇱 Netherlands |
43 |
Shionogi
4507.T |
$15.29 B | 🇯🇵 Japan |
44 |
Dr. Reddy's
RDY |
$11.88 B | 🇮🇳 India |
45 |
Teva Pharmaceutical Industries
TEVA |
$11.21 B | 🇮🇱 Israel |
46 |
Ono Pharmaceutical
4528.T |
$11.12 B | 🇯🇵 Japan |
47 |
ICON plc
ICLR |
$11.09 B | 🇮🇪 Ireland |
48 |
Bausch Health
BHC |
$10.47 B | 🇨🇦 Canada |
49 |
CRISPR Therapeutics
CRSP |
$10.42 B | 🇨🇭 Switzerland |
50 |
Curevac
CVAC |
$10.33 B | 🇩🇪 Germany |
51 |
Hualan Biological Engineering
002007.SZ |
$10.31 B | 🇨🇳 China |
52 |
Vifor Pharma
VIFN.SW |
$9.49 B | 🇨🇭 Switzerland |
53 |
Neurocrine Biosciences
NBIX |
$9.45 B | 🇺🇸 USA |
54 |
Sinopharm
1099.HK |
$9.42 B | 🇨🇳 China |
55 |
BridgeBio Pharma
BBIO |
$8.89 B | 🇺🇸 USA |
56 |
Cadila Healthcare
CADILAHC.NS |
$8.59 B | 🇮🇳 India |
57 |
Sumitomo Dainippon Pharma
4506.T |
$8.16 B | 🇯🇵 Japan |
58 |
Tilray
TLRY |
$7.89 B | 🇨🇦 Canada |
59 |
Ascendis Pharma
ASND |
$7.51 B | 🇩🇰 Denmark |
60 |
Evotec
EVT.F |
$7.19 B | 🇩🇪 Germany |
61 |
Lupin Limited
LUPIN.NS |
$7.04 B | 🇮🇳 India |
62 |
Gland Pharma
GLAND.NS |
$7.01 B | 🇮🇳 India |
63 |
Exelixis
EXEL |
$6.95 B | 🇺🇸 USA |
64 |
GW Pharmaceuticals
GWPH |
$6.81 B | 🇬🇧 UK |
65 |
KOBAYASHI Pharmaceutical
4967.T |
$6.78 B | 🇯🇵 Japan |
66 |
Torrent Pharmaceuticals
TORNTPHARM.NS |
$6.61 B | 🇮🇳 India |
67 |
Biocon
BIOCON.NS |
$6.43 B | 🇮🇳 India |
68 |
PeptiDream
4587.T |
$6.32 B | 🇯🇵 Japan |
69 |
Sarepta Therapeutics
SRPT |
$6.25 B | 🇺🇸 USA |
70 |
Perrigo
PRGO |
$6.21 B | 🇮🇪 Ireland |
71 |
Orion Corporation
ORNAV.HE |
$6.11 B | 🇫🇮 Finland |
72 |
Lundbeck
LDB.F |
$6.04 B | 🇩🇰 Denmark |
73 |
AbCellera
ABCL |
$5.87 B | 🇨🇦 Canada |
74 |
Adaptive Biotechnologies
ADPT |
$5.69 B | 🇺🇸 USA |
75 |
Intellia Therapeutics
NTLA |
$5.62 B | 🇺🇸 USA |
76 |
Santen Pharmaceutical
4536.T |
$5.49 B | 🇯🇵 Japan |
77 |
Nippon Shinyaku
4516.T |
$5.46 B | 🇯🇵 Japan |
78 |
Beam Therapeutics
BEAM |
$5.43 B | 🇺🇸 USA |
79 |
Reata Pharmaceuticals
RETA |
$5.15 B | 🇺🇸 USA |
80 |
Swedish Orphan Biovitrum
SOBI.ST |
$5.13 B | 🇸🇪 Sweden |
81 |
BB Biotech
BION.SW |
$5.08 B | 🇨🇭 Switzerland |
82 |
Alkem Laboratories
ALKEM.NS |
$5.00 B | 🇮🇳 India |
83 |
Abbott India
ABBOTINDIA.NS |
$4.69 B | 🇮🇳 India |
84 |
Laurus Labs
LAURUSLABS.NS |
$4.44 B | 🇮🇳 India |
85 |
Taisho Pharmaceutical
4581.T |
$4.39 B | 🇯🇵 Japan |
86 |
Hanmi Pharmaceutical
008930.KS |
$4.22 B | 🇰🇷 S. Korea |
87 |
Alkermes
ALKS |
$3.87 B | 🇮🇪 Ireland |
88 |
Karuna Therapeutics
KRTX |
$3.71 B | 🇺🇸 USA |
89 |
Shinpoong Pharm
019170.KS |
$3.65 B | 🇰🇷 S. Korea |
90 |
NantKwest
NK |
$3.55 B | 🇺🇸 USA |
91 |
Ipca Laboratories
IPCALAB.NS |
$3.41 B | 🇮🇳 India |
92 |
Nektar Therapeutics
NKTR |
$3.02 B | 🇺🇸 USA |
93 |
BioCryst Pharmaceuticals
BCRX |
$3.01 B | 🇺🇸 USA |
94 |
Vericel
VCEL |
$2.96 B | 🇺🇸 USA |
95 |
Dicerna Pharmaceuticals
DRNA |
$2.84 B | 🇺🇸 USA |
96 |
Rocket Pharmaceuticals
RCKT |
$2.74 B | 🇺🇸 USA |
97 |
Axsome Therapeutics
AXSM |
$2.65 B | 🇺🇸 USA |
98 |
Natco Pharma
NATCOPHARM.NS |
$2.63 B | 🇮🇳 India |
99 |
Alembic Pharmaceuticals
APLLTD.NS |
$2.59 B | 🇮🇳 India |
100 |
Editas Medicine
EDIT |
$2.54 B | 🇺🇸 USA |
World’s Largest Pharmaceutical Exporters and Importers
According to the World Trade Organization ( WTO ), these countries exported the most number of pharmaceuticals in the year 2019:
Rank | Country | Export Value (US$B) |
---|---|---|
1 | 🇩🇪 Germany | $91.4 |
2 | 🇨🇭 Switzerland | $84.8 |
3 | 🇺🇸 U.S. | $55.7 |
4 | 🇧🇪 Belgium | $55.7 |
5 | 🇮🇪 Ireland | $55.4 |
In contrast, here are the biggest importers over the same period.
Rank | Country | Import Value (US$B) |
---|---|---|
1 | 🇺🇸 U.S. | $132.4 |
2 | 🇩🇪 Germany | $59.4 |
3 | 🇧🇪 Belgium | $47.3 |
4 | 🇨🇳 China | $35.7 |
5 | 🇳🇱 Netherlands | $33.5 |
This position is hardly surprising for the U.S., where six of the world’s top 10 pharmaceutical companies are headquartered. The country also captures 45% of the global market.
The Future of Pharmaceutical Companies
If the response to the COVID-19 pandemic has taught us anything, it is that in building a patient-centered future, the pharmaceutical industry plays a key role. It has to constantly find new ways to customize medicines while researching and developing new tools and drugs.
By embracing disruptive technologies like 3D printed drugs, artificial intelligence guided therapies, and preventive medicine while working with regulatory agencies, the pharmaceutical companies will benefit from having a digital revolution.
Furthermore, emerging markets will have a more significant say in the global pharmaceutical market in the coming years. Even though ‘big pharma’ will keep raking in the massive profits they do every year, their reliance on countries like Brazil and India for research and drug production will significantly impact the years to come.


The Global Syringe Shortage Threatening Vaccine Efforts
Routine vaccination saves millions of lives every single year, according to the World Health Organization (WHO).
But even though global vaccination coverage is improving, closing the gap in immunization has led to skyrocketing demand for syringes—which is forecast to result in a major shortage that could make matters worse.
In the above infographic from NuGen Medical Devices , we explore the factors leading to the syringe shortage and take a look at the company’s innovative needle-free solution that could play an important role in closing the immunization gap.
The Immunization Gap
Even before the COVID-19 pandemic , millions of people around the world struggled to get access to routine vaccinations.
In fact, as of 2019 more than 19 million children around the world were considered to be “zero-dose” which means that they did not receive any routine vaccinations.
Moreover, when the COVID-19 pandemic hit, global immunization dropped even further with 25 million children missing out on routine vaccines in 2021 alone.
Why is Immunization So Important?
Vaccinations prevent against over 20 life-threatening diseases and save between 2-3 million deaths per year, making them—as the WHO describes—the foundation of healthcare systems and an indisputable human right.

As countries work through a backlog of vaccinations to close the immunization gap that has worsened since the pandemic, demand for syringes has significantly increased.
The Result: A Global Syringe Deficit
In 2022, the WHO warned that we could see a shortage of up to 2 billion syringes if manufacturing can’t keep up. This could result in the severe disruption to routine vaccinations and promote unsafe recycling of syringes in order to administer vaccines.
But the issue goes far beyond a supply shortage of syringes. COVID-19 has brought conventional syringe vaccines into sharp focus, with many criticizing the challenges associated with them.
The Challenge | |||
Vaccine Hesitancy:
1 in 10 Americans have an extreme fear of needles and therefore will avoid vaccination. |
Affordability:
The cost of essential syringe vaccination makes them inaccessible for people living in low and middle income countries. |
Cost of Logistics:
Geographical constrains, a lack of infrastructure, and the need to keep vaccines at sub-zero temperatures prevent them from reaching those who need it the most. |
Biohazardous Waste:
7.8 billion needles are discarded in the U.S. every year. |
The Solution | |||
Reduce Fear:
Needle-free devices remove the fear of syringes. |
Reduce Costs:
Needle-free devices are lower in cost per injection compared to conventional needles. |
Minimizes Cold Chain:
NuGen MD’s next generation powder injectables minimize the need for a cold chain (keeping vaccines at sub-zero temperatures) entirely. |
Sustainable Needles:
Needle-free technology reduces environmental waste significantly. |
With conventional needles facing so many challenges, it’s no surprise that investors are taking interest in viable alternatives. What’s more, these alternatives don’t just apply to vaccinations, they can also work for people with diabetes, dentists, and pet care.
Enter Needle-free Devices from NuGen MD
Needle-free devices have the potential to bridge the gap in immunization amid the global syringe shortage, solve some of the key challenges limiting vaccine uptake, and more importantly, benefit the lives of millions of people.
How Do They Work?
NuGen’s needle-free devices use a simple spring-loaded mechanism which uses pressure to release the liquid drug and penetrate the skin. In less than one-tenth of a second, the drug is dispensed more safely and evenly compared to needle syringes. It’s also virtually painless and leaves no mark on the skin.
>>> Interested in investing in NuGen Medical Devices? To learn more about their plans to pioneer the future of needle-free drug delivery, click this link now.

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