Ranked: Biotoxins in Nature, by Lethal Dose
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Biotoxins: Poisons of the Natural World
Biotoxins are harmful substances that come from living organisms.
They can take many forms, from the venom of a snake or spider to the neurotoxins produced by certain types of algae or microbes.
In the infographic above, we look at some common biotoxins in the natural world and rank them based on how deadly they are to an average 70 kg (154 lb) human being.
Ranking Biotoxins on a Toxic Scale
A basic concept in toxicology is that “only the dose makes the poison”. Everyday harmless substances like water have the potential to be lethal when consumed in large enough concentrations. Measuring a lethal dosage is very difficult.
First, living things are complex: factors like size, diet, biochemistry, and genetics vary across species. This makes it difficult to qualify toxicity in a universal way.
Second, individual factors like age or sex can also affect how deadly a substance is. This is why children have different doses for medications than adults.
Third, how a poison is taken into the body (orally, intravenously, dermally, etc.) can also impact its deadliness.
As a result, there are many ways to measure and rank toxicity, depending on what substance or organism is under investigation. Median lethal dose (LD50) is one common way for measuring toxicity. LD50 is the dose of a substance that kills 50% of a test population of animals. It is commonly reported as mass of substance per unit of body weight (mg/kg or g/kg). In the graphic above, we curate LD50 data of some select biotoxins found in nature and present them on a scale of logarithmic LD50 values.
What’s surprising is just how potent some toxins can be.
Bits and Bites about Biotoxins
While one would think that biotoxins are avoided at all costs by humans, the reality is more complicated. Here are some interesting facts about biotoxins present in nature, and our unusual relationships with the organisms that create them:
1. Fungi and molds make poisons called mycotoxins
Mycotoxins are a global problem. They affect crops from many countries, and can cause significant economic losses for farmers and food producers.
2. Phytotoxins can defend plants…and attack cancer
Plants use phytotoxins to defend themselves other organisms, like humans. Urushiol, for example, is the main toxic component in the leaves of poison ivy, poison oak, and sumac. But the Pacific yew tree produces taxol that’s valuable in chemotherapy treatments.
3. Fire salamander toxin is an ingredient in Slovenian whisky
Though not widely available, some whisky makers in Slovenia use samandarine from the fire salamander to create a psychedelic alcohol.
4. Ciguatoxins exist in the guts of reef fish
Very unique species of bacteria living in the digestive tract of reef fishes make ciguatoxin. They transmit this poison to other organisms when the host fish is eaten.
5. Pufferfish are deadly, but also delicious
Pufferfish contain tetrodotoxin, a potent neurotoxin in their ovaries, liver, and skin called tetrodotoxin. Despite being a delicacy in many countries around the world, it has a lot of strict regulations because of its ability to kill people. In Japan, for example, only specially licensed chefs can prepare pufferfish for consumption.
6. Batrachotoxin is lethal to the touch
The skin of some poison dart frogs secretes a deadly substance called batrachotoxin. It is so potent that simply touching the poison can be fatal. Indigenous people of Central and South America used batrachotoxin to poison the tips of hunting weapons for centuries.
7. Botox contains the most deadly biotoxin known
Commercial botox uses an extremely small amount of biotoxin from a microbe called Clostridium botulinum . It paralyzes the muscles, preventing contraction (i.e. wrinkling). It is the deadliest known biotoxin on Earth. One gram of botulinum toxin can kill up to one million people.
Caveats of Measuring and Reporting Biotoxicity
While we use LD50 data to rank biotoxicity, it isn’t an exact science. There is room for improvement.
For starters, no LD50 data exists for humans. That means data from other organisms has to be converted to apply to humans. There is a lot of contention amongst scientific communities about how accurate this is.
There has also been an increasing effort to move to new methods of measuring toxicity that are not harmful to animals. Several countries, including the UK, have taken steps to ban the oral LD50, and the Organisation for Economic Co-operation and Development (OECD) abolished the requirement for the oral test in 2001.
Now, new ways of evaluating toxicity are under investigation, like cell-based screening methods.
Correction: Water was mislabeled on a previous version of the infographic. Full sources here
Vintage Viz: China’s Export Economy in the Early 20th Century
This pie chart, circa 1914, is a fascinating breakdown of China’s export economy just prior to World War I.
Vintage Viz: China’s Export Economy in the Early 20th Century
“The past is a foreign country; they do things differently there” is the oft-quoted first line of L.P. Hartley’s 1953 novel, The Go-Between .
A statement that is as profound as it is banal. In other words, when we do history, we’re a bit like tourists. If we really want to understand the past, we have to think like a local.
The infographic above, Aspects of Principal Exports of Chinese Goods to Foreign Countries , is the first in a series that we’re calling Vintage Viz , which presents a historical visualization along with the background and analytical tools to make sense of it.
Today, the People’s Republic of China is the second largest economy in the world, a permanent member of the UN Security Council, and a growing military power . But at the dawn of the 20th century, things were much, much different.
Opium and the Opening of China to the West
Early Sino-Western trade was restricted by the Qing emperors to three ports, and after 1757, just one, in what became known as the Canton System. This name came from the one remaining port city of the same name, present-day Guangzhou.
Foreign trade was tightly monitored and subject to stiff tariffs, and Western traders chafed under these restrictions. So when in 1839, Chinese authorities moved to shut down opium smuggling—an important source of profit for foreign merchants—Western powers saw their chance and used the pretext to revise the terms of trade by force.
In what became known as the Opium Wars, 1839-1842 and 1856-1860, first Great Britain and then an Anglo-French alliance defeated imperial China and imposed punitive treaties that included indemnities and lowered tariffs, but also expanded the number of ports open to foreign traders, first to five and by 1911, to more than 50.
Westerners were exempted from local laws, Christian missionaries were allowed to proselytize freely, and the opium trade was legalized. Hong Kong was also ceded to Great Britain at this time.
The Treaty Port Era, also known as the Century of Humiliation , was perhaps too much for the country to bear. The weakened central government was beset by popular unrest, including the Taiping Rebellion (1850–64), which killed 20 million people, and the Boxer Rebellion (1899-1901), so-named for the secret society that led the movement, the Righteous and Harmonious Fists.
Eventually, the last Chinese emperor was deposed and a republic declared in 1911. Nevertheless, the government was too weak to impose its will, and was repeatedly challenged by warlords.
So as we approach the outbreak of the First World War in 1914, and the period covered by our visualization, we find China weakened internally by civil strife, and externally by Western powers.
The History of this Century-Old Pie Chart
Aspects of Principal Exports of Chinese Goods to Foreign Countries captures Chinese exports for 1914, and comes from The New Atlas and Commercial Gazetteer of China: A Work Devoted to Its Geography & Resources and Economic & Commercial Development .
Originally published in 1917 and edited by Edwin J. Dingle for the Far Eastern Geographical Establishment, the volume contains a wealth of data for the period. According to the book’s Preface, it “seeks to give all the information that is essential to the business-man in regard to a country… about which less is known than in regard to any similar area in the world.”
The visualization breaks down total Chinese exports for 1914 in haikwan taels (hk. tls.), a unit of silver currency used to collect tariffs. In 1907, one haikwan tael was worth $0.79 U.S. dollars.
Official figures come from the Chinese Maritime Customs Service . This was set up by foreign consuls after the First Opium War to collect tariffs to guarantee the payment of treaty indemnities.
Exports in 1914 represented 345 million hk. tls., a 14.4% decrease from 1913, likely owing to the outbreak of the First World War that same year.
Apart from “Other Metals and Minerals, Sundries, etc,” which served as a catch-all category, the largest categories were silks and teas of various types, representing 22.6% and 10.4% of total exports respectively.
|Export Item||Value (hk. tls.)|
|Eggs, Fresh, Preserved and Frozen||4,192,535|
|Fire crackers and fire works||2,435,841|
|Mats and Matting||3,326,819|
|Oil, Bean and Nutgalls||6,027,967|
|Other Metals and Minerals, Sundries, etc||74,449,181|
|Silk Piece Goods||10,841,472|
|Silk, Raw, not Steam Filature||2,811,367|
|Silk, Raw, White, Steam Filature||37,384,485|
|Silk, Raw, Wild not Filatures||4,072,777|
|Silk, Raw, Yellow Steam Filatures||1,267,413|
|Silk, Raw, Yellow, (not Steam Filature)||4,439,073|
|Skins and Hides Undressed (Cow and Buffalo)||13,499,340|
|Skins, Goat Untanned||3,207,974|
|Tallow, Animals and Vegetables||3,175,270|
|Tea Brick, Black||6,711,019|
|Tea Brick, Green||2,323,259|
|Tin, in Slabs||7,978,558|
Below are some more details that emerge from this visualization.
All the Tea in China
The Chinese tea trade was the subject of another visualization in the Atlas. It shows that China had been steadily losing ground to British India. Between 1888-1892 Chinese exports to Great Britain were 242 million pounds against India’s 105 million pounds. By 1912-1913, India had surpassed China to export 279 million pounds against 198 million pounds.
In 1914, the majority of Chinese exports went to Russia, 902,716 piculs in all. A picul is equal to “as much as a man can carry on a shoulder-pole” or about 133 pounds.
The Silk Road to Profits
Silk has long been in demand in the West as a luxury good, giving its name to the overland trade route that connected East and West for centuries: the Silk Road.
In 1914, China was the largest producer and exporter of silks in the world. On an annual basis, China averaged 14 million pounds, compared to the number two spot, Japan, at 11 million pounds, and number three, Italy, at 9 million pounds. Together, these three controlled 81.7% of the global silk trade.
The Opium of the Masses?
The opium trade, the pretext that opened China to foreign trade, was still big money in 1914.
A total of 37 million hk. tls. were imported in 1914 from India, up 11.9% from 1908. This is actually down from a peak of 41 million hk. tls. in 1913.
In 1907, China signed the Ten Year Agreement with India, which ultimately phased out the opium trade. By 1917 the trade was all but extinguished.
Back to the Future
The Aspects of Principal Exports of Chinese Goods to Foreign Countries is a far cry from the contemporary trade picture. China’s top export in 2021 was in the category “telephones for cellular networks or other wireless networks,” and was worth $147.1 billion .
But it’s worth noting that China today is a direct result of this period. The resentment created during the Century of Humiliation would eventually help lead to Mao Zedong, the Long March, and the establishment of the People’s Republic of China.
And in 1979, the Chinese central government would set up the first of their own “treaty ports,” in the form of special economic zones, places where foreign companies could set up shop. But this time, it wasn’t foreign powers who were making the rules.
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